Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion

Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion

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Background: Postoperative abdominal adhesion is a prevalent complication following abdominal surgery, with the incidence of adhesion reaching up to 90%, which may precipitate a range of adverse outcomes.Although fibrous membranes loaded with various anti-inflammatory or other drugs have been proposed for anti-adhesion, most of them suffer from sten jacket m drug-induced adverse effects.Methods: In this study, a lecithin-based electrospun polylactic acid (PLA) nanofibrous membrane (L/P-NM) was developed for the prevention of postoperative abdominal adhesion, utilizing the hydration lubrication theory.The loaded zwitterionic lecithin allows the nanofiber surface to strongly bind water molecules to create a hydration lubrication interface.Results: As the TGA results show, the content of animed blue lotion topical spray bound water in the nanofibers increased significantly with the increase in the lecithin content.

Tribological test results show that L/P-NM reached a minimum coefficient of friction (COF) of about 0.112.Additionally, the developed nanofibrous membranes possess favorable tensile property and biocompatibility.Rat postoperative abdominal adhesion model evaluation results demonstrated that L/P-NM possesses significant anti-adhesive performance, with an adhesion score of only 1.Conclusions: Therefore, this study offers a promising strategy for efficiently preventing abdominal adhesion.